Exhibit 12.1

STATEMENT REGARDING THE COMPUTATION OF RATIO OF COMBINED FIXED CHARGES AND

PREFERENCE DIVIDENDS TO EARNINGS

 

     Three Months Ended
March 31,

2009
    Year Ended December 31,  
    
     2008     2007     2006     2005     2004  

Fixed charges:

            

Interest expense

   $ 1,000     $ 21,000     $ 96,000     $ 272,000     $ 533,000     $ 795,000  

Estimated interest portion of rent expense

     446,000       1,859,000       1,967,000       2,057,000       2,130,000       2,152,000  
                                                

Total fixed charges

   $ 447,000     $ 1,880,000     $ 2,063,000     $ 2,329,000     $ 2,663,000     $ 2,947,000  
                                                

Earnings:

            

Loss from continuing operations before income taxes

   $ (8,244,000 )   $ (36,896,000 )   $ (35,894,000 )   $ (23,148,000 )   $ (24,357,000 )   $ (23,733,000 )

Add: Fixed charges

     447,000       1,880,000       2,063,000       2,329,000       2,663,000       2,947,000  

Amortization of capitalized interest

     —         —         —         —         2,000       13,000  
                                                

Total earnings

   $ (7,797,000 )   $ (35,016,000 )   $ (33,831,000 )   $ (20,819,000 )   $ (21,692,000 )   $ (20,773,000 )
                                                

Ratio of combined fixed charges and preference dividends to earnings(1)

     —         —         —         —         —         —    

 

(1) For the years ended December 31, 2008, 2007, 2006, 2005 and 2004 and the three months ended March 31, 2009, the earnings were insufficient to cover fixed charges by $36,896,000, $35,894,000, $23,148,000, $24,357,000, $23,733,000 and $8,244,000, respectively.