Exhibit 12.1

STATEMENT REGARDING THE COMPUTATION OF RATIO OF COMBINED FIXED CHARGES AND

PREFERENCE DIVIDENDS TO EARNINGS

 

     Nine Months Ended
September 30,

2009
    Year Ended December 31,  
    
     2008     2007     2006     2005     2004  

Fixed charges:

            

Interest expense

   $ 2,000      $ 21,000      $ 96,000      $ 272,000      $ 533,000      $ 795,000   

Estimated interest portion of rent expense

     1,311,000        1,859,000        1,967,000        2,057,000        2,130,000        2,152,000   
                                                

Total fixed charges

   $ 1,313,000      $ 1,880,000      $ 2,063,000      $ 2,329,000      $ 2,663,000      $ 2,947,000   
                                                

Earnings:

            

Loss from continuing operations before income taxes

   $ (21,249,000   $ (36,896,000   $ (35,894,000   $ (23,148,000   $ (24,357,000   $ (23,733,000

Add: Fixed charges

     1,313,000        1,880,000        2,063,000        2,329,000        2,663,000        2,947,000   

Amortization of capitalized interest

     —          —          —          —          2,000        13,000   
                                                

Total earnings

   $ (19,936,000   $ (35,016,000   $ (33,831,000   $ (20,819,000   $ (21,692,000   $ (20,773,000
                                                

Ratio of combined fixed charges and preference dividends to earnings(1)

     —          —          —          —          —          —     

 

(1) For the nine months ended September 30, 2009 and the years ended December 31, 2008, 2007, 2006, 2005 and 2004, the earnings were insufficient to cover fixed charges by $21,249,000, $36,896,000, $35,894,000, $23,148,000, $24,357,000 and $23,733,000, respectively.