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This Post-Effective Amendment relates to the following Registration Statements on Form S-3 (each, a “Registration Statement” and, collectively, the “Registration Statements”), previously filed by Fresh Tracks Therapeutics, Inc. (the “Company”), with the U.S. Securities and Exchange Commission (the “SEC”) (the share numbers and exercise price listed below do not take into account any applicable corporate actions, such as stock splits, that may have been taken in the interim):

•Registration Statement on Form S-3 (File No. 333-236757), originally filed with the SEC on February 28, 2020, as amended and declared effective by the SEC on March 19, 2020, pertaining to the registration of 1,556,420 shares of the Company’s common stock, $0.01 par value per share (“Common Stock”), including 950,000 shares held by a selling stockholder and 606,420 shares issuable to such selling stockholder upon exercise of a warrant to initially purchase such shares of Common Stock at an exercise price of $0.01 per share; and

•Registration Statement on Form S-3 (File No. 333-254037), originally filed with the SEC on March 9, 2021 and declared effective by the SEC on March 17, 2023, pertaining to the registration of up to $150,000,000 in the aggregate of Common Stock, preferred stock, debt securities, stock purchase contracts, warrants, rights and units of the Company, in any combination.

The Company is filing this Post-Effective Amendment to the Registration Statements to withdraw and remove from registration any and all shares of Common Stock and all other securities registered but unsold or otherwise unissued under the Registration Statements.

On September 18, 2023, the Company’s Board of Directors (the “Board”) approved the liquidation and dissolution of the Company (the “Dissolution”) and the plan of liquidation and dissolution (the “Plan of Dissolution”) which, following approval by the Company’s stockholders at the special meeting initially held on November 16, 2023, and reconvened on November 30, 2023 and December 15, 2023, authorizes the Company and the Board to Dissolve the Company in accordance with the Plan of Dissolution.

In connection with the Dissolution and the Plan of Dissolution, the Company has terminated any and all offerings of its securities pursuant to its existing registration statements under the Securities Act of 1933, as amended, including the Registration Statements. In accordance with the undertakings pursuant to Item 512 of Regulation S-K made by the Company in the Registration Statements, the Company hereby removes and withdraws from registration all securities of the Company registered pursuant to the Registration Statements that remain unsold or otherwise unissued as of the date hereof. Each Registration Statement is hereby amended, as appropriate, to reflect the deregistration of such securities, and the Company hereby terminates the effectiveness of the Registration Statements.

Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-3 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Boulder, State of Colorado, on December 18, 2023.

Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed by the following persons in the capacities indicated on December 18, 2023.

Signature

Title

/s/ Albert N. Marchio, II

Chief Executive Officer, Chief Financial Officer and Director

Albert N. Marchio, II

(Principal Executive Officer and Principal Financial Officer)

/s/ Aaron Fox-Collis

Vice President of Finance & Chief Accounting Officer

Aaron Fox-Collis

(Principal Accounting Officer)